Moderate hyperhomocysteinemia is a highly prevalent defect in Spanish patients with venous thromboembolic disease.
نویسندگان
چکیده
Recent studies suggest that mild hyperhomocysteinemia may be a risk factor for venous thromboembolic disease (VTED). In this work we evaluated the prevalence of moderate hyperhomocysteinemia in patients with VTED in our area. We found hyperhomocysteinemia in 23.4% of 64 patients studied compared with 7.35% of 68 healthy controls (p = 0.014). Our results suggest that moderate hyperhomocysteinemia is one of the most prevalent abnormalities associated with VTED.
منابع مشابه
Vitamin B12 Deficiency and Thrombosis
Purpose: Thromboembolic diseases are multi-factorial. Hyperhomocysteinemia (HH) is one of these factors. Vitamin B12 deficiency is acquired reasons for HH. HH is a risk factor for arterial and venous thrombosis. The incidence of thrombosis is high due to increase of homocystein levels in HH associated with vitamin B12 deficiency. However, this situation is not clear and there are opposing views...
متن کاملEvaluation of the Frequency of Risk Factors in Venous Thromboembolic Patients Admitted to Ekbatan and Farshchian Hospitals in Hamadan from 2012 to 2017
Background and Objective: Venous thromboembolism is one of the major causes of mortality worldwide. Various environmental and genetic factors are known as risk factors for this disease. Therefore, this study aimed to investigate the frequency of risk factors in patients with venous thromboembolism admitted to Ekbatan and Farshchian hospitals in Hamadan from 2012 to 2017. Materials and Methods:...
متن کاملDiagnosis of thromboembolic disease: Combined ventilation perfusion lung scan and compression ultrasonography
The clinical management of pulmonary embolism and deep venous thrombosis of the legs are similar and requires prolonged anticoagulation therapy. The standard diagnostic approach in patients suspected of pulmonary embolism is ventilation-perfusion (V/Q) lung scan and compression ultrasonography to detect deep venous thrombosis. This retrospective study analyzed the role of V/Q lung scan an...
متن کاملFamilial Thrombophilia Associated With Homozygosity for the Cystathionine b-Synthase 833T3C Mutation
Severe hyperhomocysteinemia due to cystathionine b-synthase (CBS) deficiency is a strong risk factor for premature cardiovascular disease. Among untreated patients, '50% have suffered a thromboembolic event by 30 years of age. We report on 3 sisters with severe hyperhomocysteinemia due to homozygosity for the CBS 833T3C mutation. These patients, who displayed no other known thrombophilic predis...
متن کاملFamilial Thrombophilia Associated With Homozygosity for the Cystathionine
Severe hyperhomocysteinemia due to cystathionine b-synthase (CBS) deficiency is a strong risk factor for premature cardiovascular disease. Among untreated patients, '50% have suffered a thromboembolic event by 30 years of age. We report on 3 sisters with severe hyperhomocysteinemia due to homozygosity for the CBS 833T3C mutation. These patients, who displayed no other known thrombophilic predis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Haematologica
دوره 83 12 شماره
صفحات -
تاریخ انتشار 1998